Sildenafil vs Tadalafil

Sildenafil vs. Tadalafil: Key Differences

In Erectile Dysfunction, Premature Ejaculation, Sex by userLeave a Comment

Sildenafil and Tadalafil are the active ingredients in Viagra and Cialis. Being the active ingredients means that they are the only key ingredients that work to inhibit PDE-5, an enzyme that helps restrict the rigidity of the penis. They exist both in the smooth muscle cells that line the penis and in the lungs.

As PDE-5 inhibitors, both Sildenafil (Viagra) and Tadalafil (Cialis) help men to both get and maintain erections. However, they do not guarantee erections. Still, the success rate is high, hovering somewhere in the range of 80% with decades of research behind them.

Both Viagra and Cialis are now off-patent. That means that the active ingredients of Sildenafil (seen in Viagra) and Tadalafil (seen in Cialis) are now offered as generic drug supplements that are far more cost effective than their brand name counterparts. Plus, the generic versions offer the same results as the branded pills themselves.

Now, if you’re comparing Sildenafil with Tadalafil, you’re likely wondering which one is better. The answer clearly depends on your current situation. Any comparison of Sildenafil vs. Tadalafil is unique to the individual taking the drug. Since there are so many factors involved, let’s look at the key ones.

What’s The Big Difference Between Sildenafil and Tadalafil?

There are a few factors to consider when comparing these active ingredients in the most popular erectile dysfunction drugs, Viagra (Sildenafil) and Cialis (Tadalafil). There are some key takeaways on whee these two drugs differ. For example, things like activation time and longevity are important considerations.

When we talk about activation time, we’re referring to the period between ingestion of the pill and activation. When you swallow Sildenafil or Tadalafil, it takes time for these PDE-5 inhibitors to get to work. They land in the stomach and are then absorbed into the blood stream through natural digestive processes.

Since Sildenafil and Tadalafil are primarily oral drugs, activation isn’t instantaneous. It isn’t like injecting the active ingredient directly into your bloodstream. For that reason, they take time to act. This activation time is important because it impacts the spontaneity in your ability to have sex. That, in turn, is impacted by your lifestyle.

For example, if your partner is in the mood now, and you have to wait several hours for the drug to kick in, it might take away from the experience of having spontaneous sex. For that reason, whether you choose Sildenafil or Tadalafil also depends on your lifestyle and how spontaneous you prefer to be.

Activation Periods of Sildenafil vs. Tadalafil

Most people care about how long it takes for their ED medication to kick in. Whenever you’re considering either Sildenafil or Tadalafil, you should think about the activation period. Both have activation periods that remove the spontaneity from any sexual encounter.

Sildenafil: 30 Minutes to 1 Hour

Viagra (also known as the “little blue pill”) contains the active ingredient, Sildenafil. Sildenafil takes about 30 minutes to an hour to kick in. In rare cases, it takes a bit longer. One study found that it takes roughly 27 minutes for Sildenafil to kick in. That’s relatively fast if you’re looking to be spontaneous in your sexual activity.

Tadalafil: 1 to 2 Hours

Cialis (also known as “the weekender pill”) contains the active ingredient, Tadalafil. Tadalafil takes roughly 1 to 2 hours to activate. This might vary based on how full or empty your stomach is. It’s recommended that when taking any ED medication that you do so on a fairly empty stomach to speed up the absorption rate.

Longevity of Sildenafil versus Tadalafil

When we talk about the longevity of drugs, we’re talking about how long they last in the system. When drug companies refer to the plasma half-life of a drug, they’re talking about the length of time it takes for the concentration fo the drug to be cut in half in the bloodstream.

Both Sildenafil and Tadalafil have very different plasma half-lives. Therefore, they have very different longevities of effect. While Sildenafil has a plasma half-life of 4 hours, Tadalafil’s is 17.5 hours. That’s also why Cialis is known as the weekender pill, since its effects can last throughout an entire weekend (up to 36 hours or so in most cases)

This distinction is important. If you’re looking to be more spontaneous, even though Tadalafil takes longer to activate than Sildenafil, it also lasts longer. With the ability to get and maintain an erection for virtually the entire weekend, Tadalafil is great for those looking for more spontaneity in their sex lives.

This means that you don’t have to take a pill just before sex. With Sildenafil, which lasts for a maximum of 4 hours, you won’t have the spontaneity because the plasma half-life is far shorter than Tadalafil. Depending on your personal preferences and sexual lifestyle, one or the other might be better.

When you’re considering Sildenafil or Tadalafil, this is an important distinction to make. This is primarily the determining factor for most. Since both of these ED drugs have similar side effects and similar effectiveness rates, men primarily choose based on which of these lasts longer.

Daily Usage Versus On-Demand ED Medications

Whether you’er taking one of these ED drugs on demand, or you’re looking for a daily dose, it could mean the difference between deciding between Sildenafil and Tadalafil. For the most part, Sildenafil is prescribed for on-demand usage as opposed to daily dosage.

That’s because you’ll tend to get higher dosage amounts of Sildenafil. These pills often start at 25mg and range up to 50mg and 100mg. But they should not be taken more than once per day and you should never exceed the maximum daily recommended limit of 100mg of Sildenafil.

Tadalafil, on the other hand, comes in smaller doses. We’re talking more like 2.5mg to 20mg. It’s also recommended that Tadalafil be taken on a daily basis as opposed to being taken in an on-demand scenario. This provides a more long-term solution to your ED needs and gives you more spontaneity with your partner.

That means that Tadalafil will help you right when the mood strikes. Sildenafil will not. If you’re looking for spontaneity in your encounters, the clear choice is Tadalafil. As long as you’re okay with a daily dosage, Tadalafil would be the clear choice in that instance.

On the other hand, if you’re not looking for spontaneity and you don’t mind taking a pill roughly 30 minutes before your “planned” encounter, then Sildenafil might be the right choice. It’s a stronger pill that activates quickly, but won’t last as long.

Price Differences

Sildenafil and Tadalafil are both the generic versions of branded drugs that are now off-patent. Since these patent expirations, generic versions of Viagra and Cialis have started to take off with companies introducing their own variations using these key active ingredients.

If you’re looking for branded versions of Sildenafil (Viagra) or Tadalafil (Cialis), you’re looking at high costs. Alpha Now does supply the branded versions of these drugs, but also provides their generic counterparts. In fact, Alpha Now has its own PDE-5 inhibitor that actually lasts longer than Sildenafil but a bit shorter than Tadalafil.

However, for the most part, Sildenafil and Tadalafil are similar in terms of cost. One doesn’t cost much more than the other when we’re talking about the generic versions. However, keep in mind that Tadalafil will be taken in lower doses since it’s more of a daily ED drug so your supply will likely be used up quicker than if you’re taking Sildenafil.

Known Drug Interactions

One other factor to consider when you’re comparing Sildenafil with Tadalafil is the interaction with other drugs. This also depends on what types of other illnesses or diseases you have and what medications you’re taking for them. Clearly, this is going to take the advice from a doctor before you go ahead with either Sildenafil or Tadalafil.

However, as a general rule of thumb, understand this. Sildenafil and Tadalafil are vasodilators. Keep in mind that in order to get an erection, 6 times the regular blood flow is required to the penis. In order to achieve that blood flow to the penis, PDE-5 is inhibited and a vasodilation occurs. Vasodilation is simply the opening (widening) of blood vessels.

When blood vessels dilate or widen, it allows more blood to flow through them. It’s like having a highway with 6 lanes as opposed to one lane. Suddenly, 6 times more traffic can flow across the roads in the same period. Think of vasodilation in the same way.

However, vasodilation can also lead to some problems that conflict with other conditions. For example, when your blood vessels open, it causes your blood pressure to drop. That could conflict with a variety of medical conditions.

For example, for patients that are taking nitrates that already lower blood pressure, the combination of another drug that lowers blood pressure could cause fatal. Thus, if you’re on nitrates, it’s not recommended to take ED medication. And especially not Tadalafil.

Also, if you’re taking things like Nizoral, Sporanox, Crixivan or Norvir, it might deter the breakdown of Tadalafil in the body. This could lead to severe elongated erections. For that reason, doses of Tadalafil should be greatly reduced or limited, especially when first starting out if you’re on any of these drugs.

Are Sildenafil & Tadalafil Different Than The Brand Names?

Most people ask whether Sildenafil (Viagra) and Tadalafil (Cialis) are different than their brand-name counterparts. They are not. They each have the same active ingredient. In Viagra, the primary active ingredient is Sildenafil. In Cialis, it’s Tadalafil. There are non-active ingredients in both pills, but those are the only active ingredients.

For that reason, the generic versions are no different than their brand-name counterparts. The only variation can come in the production of the pills. Only buy Sildenafil and Tadalafil from reputable sources. Alpha Now has its own FDA-approved lab, so all of our ED medications are pharmaceutical grade and made to the highest quality.

However, not all other sources where you might buy Sildenafil or Tadalafil might hold themselves to the same standards. They don’t. So, although the generic versions of these drugs are no different than the brand-name versions, their production methods could cause some variations in how effective they are.

Other Things To Consider

There are other considerations when comparing Sildenafil and Tadalafil. Aside from understanding the activation periods, dosage amounts, longevity, side effects and so on, there are some other things that you should take into careful consideration.

For example, when taking Sildenafil, although it’s recommended to take on an empty stomach, having a full stomach won’t impact the effects of it very much. It will still need to go through the natural absorption processes, but since these are often prescribed in higher dosages, there is not much of an altered affect if you take it on a full stomach.

Tadalafil, on the other hand, is drastically impacted by a full or empty stomach. When it comes to Tadalafil, it’s recommended that it be taking on an empty stomach. Not on a full stomach. Keep in mind that these dosage amounts of drastically smaller. We’re talking 2.5mg to 20mg of Tadalafil versus 25mg to 100mg of Sildenafil.

Ready To Get Started?

Whether you’re interested in taking Sildenafil or Tadalafil, if you’re ready to get started today, all you have to do is click here to get access to the Alpha Club and take a short survey so that we can prescribe you either medication online. You can do this from the comfort of your home without ever having to go into a doctor’s office in person,.

This removes a lot of the pain and the embarrassment that most men go through when having to go to their primary care physicians or to a doctor that they might not even know very well. With Alpha Now, you can literally take the entire exam online. You’ll never have to go anywhere. Whether it’s on your desktop or mobile device, you can chat with a doctor now.

The entire process happens online. Then, we can actually prescribe you either Sildenafil or Tadalafil. Then, we’ll ship it straight to your doorstep. It’s the easiest, lowest-friction method for getting your ED medications. Get started today.